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  • Title: Primary and secondary osteosarcoma of the face: a rare childhood malignancy.
    Author: Maes P, Brichard B, Vermylen C, Cornu G, Ninane J.
    Journal: Med Pediatr Oncol; 1998 Mar; 30(3):170-4. PubMed ID: 9434826.
    Abstract:
    BACKGROUND: Osteosarcoma of the head and neck, especially primary forms, remains a rare and highly malignant tumor. PATIENTS: This report describes two patients who developed an osteosarcoma of the face more than ten years after treatment for bilateral retinoblastoma. We also report a third patient who presented with a primary osteosarcoma of the right superior maxilla which is one of the rarest tumors encountered in childhood oncology. CONCLUSIONS: The mainstay of therapy is surgical resection with negative margins. Careful, long-term follow-up of survivors of hereditary retinoblastoma is essential, especially for those given radiation therapy.
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