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  • Title: Successful treatment of cytophagic histiocytic panniculitis by cyclosporin A: a case report.
    Author: Viravan S, Wisuthsarewong W, Manonukul J, Tanphaichitr VS.
    Journal: Asian Pac J Allergy Immunol; 1997 Sep; 15(3):161-6. PubMed ID: 9438549.
    Abstract:
    This is a report of a case, 7 1/2 year-old-boy having chronic febrile and recurrent crops of painful subcutaneous nodules on lower extremities, which had previously been diagnosed as Weber-Christian disease, which progressed to have cytophagic histiocytic activity in the skin, bone marrow with abnormal liver function and hemorrhagic diathesis. He was subsequently treated with corticosteroid without good response. After he was diagnosed as having cytophagic histiocytic panniculitis, cyclosporin A was administered intravenously in an initial dosage of 1 mg/kg/day and in oral maintenance dose of 10 mg/kg/day with a successful response and the patient completely recovered within 6 months with mild hypertension as an adverse effect.
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