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  • Title: [Febrile neutropenia: empiric antibiotic therapy from 1975 to 1997].
    Author: Klastersky J.
    Journal: Rev Med Brux; 1997 Oct; 18(5):323-7. PubMed ID: 9441328.
    Abstract:
    Monotherapy with ceftazidime, cefepime, imipenem or meropenem for the empiric treatment of febrile neutropenia appears as effective as the combination therapy involving aminoglycosides. However, empiric therapy with a combination of a beta-lactam plus an aminoglycoside is a reasonable decision under circumstances where Gram negative sepsis is very likely. Monotherapy is usually associated with a modest rate of response in infections caused by Gram positive organisms. In about 30% of the patients, a glycopeptide will be added at some point, because the response to the initial therapy is not considered optimal.
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