These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Psychosis during chronic levodopa therapy triggered by the new antidepressive drug mirtazapine.
    Author: Normann C, Hesslinger B, Frauenknecht S, Berger M, Walden J.
    Journal: Pharmacopsychiatry; 1997 Nov; 30(6):263-5. PubMed ID: 9442549.
    Abstract:
    We report the case of a patient developing psychosis after the addition of mirtazapine, a novel antidepressant enhancing serotonergic neurotransmission, to a chronic levodopa regimen. There was complete and rapid recovery upon low-dose clozapine treatment. To our knowledge, this is the first published case of a mirtazapine-levodopa interaction and the second case report of a psychosis induced by a serotonergic antidepressant in a patient with Parkinson's disease (PD). This phenomenon might be due to a postsynaptic serotonin receptor supersensitization caused by low central serotonin levels in treated PD.
    [Abstract] [Full Text] [Related] [New Search]