These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Increased urinary-free cortisol outputs in diabetic patients.
    Author: Roy MS, Roy A, Brown S.
    Journal: J Diabetes Complications; 1998; 12(1):24-7. PubMed ID: 9442811.
    Abstract:
    We previously reported that diabetic patients show evidence of dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To extend this work, we examined urinary-free cortisol (UFC) outputs in diabetic patients and whether or not they relate to diabetic complications. We compared a group of 35 insulin-dependent diabetic outpatients with a group of 32 normal controls for 24-h UFC outputs and examined the patients for relationship between UFC outputs and diabetic complications. Diabetic patients had significantly greater 24-h UFC outputs than controls. There was a significant positive correlation between 24-h UFC outputs and duration of diabetes. There were trends for patients with either diabetic retinopathy or diabetic cardiovascular complications to have higher 24-h UFC outputs than patients without these complications. These results further show that diabetic patients have mild dysregulation of the HPA axis. This dysregulation is related to longer duration of diabetes. A larger sample is needed to examine further for a relationship to diabetic complications.
    [Abstract] [Full Text] [Related] [New Search]