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  • Title: Transneuronal down regulation of vestibulo-ocular neurons following vestibular ablation.
    Author: Gacek RR, Schoonmaker JE.
    Journal: Acta Otolaryngol; 1997 Nov; 117(6):810-4. PubMed ID: 9442818.
    Abstract:
    Unilateral ablation of vestibular input causes lasting morphological changes bilaterally in superior vestibulo-ocular neurons (SVON). The present study was performed to see if these changes in SVON are more pronounced after bilateral vestibular neurectomy. Twenty-three SVON from both vestibular nuclei of 2 cats sacrificed 8 weeks after bilateral ablation were examined utilizing morphometric ultrastructural techniques. There was a significantly greater somal atrophy, loss of synaptic profiles, rough endoplasmic reticulum and polyribosomes compared to unilateral neurectomy. These changes indicate a down regulation that is proportional to the level of deafferentation and may account for functional deficits seen in the vestibulo-ocular reflex after peripheral ablation.
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