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  • Title: Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder.
    Author: Smedley D, Somers G, Venter D, Chow CW, Cooper C, Shipley J.
    Journal: Genes Chromosomes Cancer; 1998 Jan; 21(1):70-3. PubMed ID: 9443043.
    Abstract:
    Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11-12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.
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