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  • Title: Single chain observation on collapse transition in giant DNA induced by negatively-charged polymer.
    Author: Ichiba Y, Yoshikawa K.
    Journal: Biochem Biophys Res Commun; 1998 Jan 14; 242(2):441-5. PubMed ID: 9446814.
    Abstract:
    Poly-glutamic acid, a polyanion, has been shown to induce the all-or-none collapse transition in individual duplex DNAs from an elongated coil into a collapsed compact state, through the observation of single chains by fluorescence microscopy. This experimental finding is discussed in relation to the change in the higher-order structure of DNAs in the cytoplasmic space induced by a change in the concentration of polyanions, such as mRNA, as a possible route for feedback in gene expression.
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