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  • Title: Ability of lymphokine-activated killer cells to lyse mycobacteria-infected cells.
    Author: Chiplunkar SV, Deshmukh MA, Kode JA, Gangal SG, Deo MG.
    Journal: Acta Leprol; 1997; 10(4):203-8. PubMed ID: 9447253.
    Abstract:
    Lymphokine-activated killer (LAK) cells were generated by interleukin-2 activation of peripheral blood lymphocytes obtained from lepromatous leprosy (LL) patients and healthy individuals. The ability of LAK cells to lyse targets (macrophages and T-24, a bladder carcinoma cell line) infected with mycobacteria (Mycobacterium leprae and mycobacterial strain ICRC) was assessed in a 51 chromium-release assay. It was observed that LAK cells generated from LL patients and healthy individuals could preferentially lyse M. leprae or ICRC-pulsed macrophages and T-24 cells, compared to non-pulsed targets. The ability of LAK cells to kill intracellular mycobacteria was demonstrated in colony forming assays. These results indicate a promising role for LAK cells in immunotherapy of leprosy.
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