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  • Title: In vitro activity of sanfetrinem and affinity for the penicillin-binding proteins of Streptococcus pneumoniae.
    Author: Sifaoui F, Varon E, Kitzis MD, Gutmann L.
    Journal: Antimicrob Agents Chemother; 1998 Jan; 42(1):173-5. PubMed ID: 9449281.
    Abstract:
    Against penicillin-susceptible pneumococci, the activity of sanfetrinem was similar to those of penicillin, amoxicillin, cefotaxime, imipenem, and meropenem, while against penicillin-resistant strains, sanfetrinem and the carbapenems exhibited superior activity (MICs at which 90% of strains are inhibited, < or =1 microg/ml). PBP 1a in the penicillin-susceptible strain and PBP 1a and PBP 2b in the more resistant isolates seemed to be the essential penicillin-binding proteins for imipenem and sanfetrinem.
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