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  • Title: Adrenergic and peptidergic regulations of hydroxyindole-O-methyltransferase activity in rat pineal gland.
    Author: Ribelayga C, Pévet P, Simonneaux V.
    Journal: Brain Res; 1997 Nov 28; 777(1-2):247-50. PubMed ID: 9449437.
    Abstract:
    Mechanisms involved in the regulation of hydroxyindole-O-methyltransferase (HIOMT) activity were investigated in the rat pineal. Isoproterenol, db-cAMP, PACAP or VIP had no acute (6 h) effect whereas NPY, thapsigargin and a PKC activator stimulated HIOMT activity by 30-40%. Chronic stimulation (6 days) with isoproterenol, db-cAMP, or each peptide prevented the long-term decrease of HIOMT activity. Phenylephrine had neither short- nor long-term effect on enzyme activity. These results indicate that HIOMT activity is long- and short-term regulated by various neurotransmitters.
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