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  • Title: Prospects for a prophylactic HPV vaccine: rationale and future implications for cervical cancer screening.
    Author: Sherman ME, Schiffman MH, Strickler H, Hildesheim A.
    Journal: Diagn Cytopathol; 1998 Jan; 18(1):5-9. PubMed ID: 9451552.
    Abstract:
    Cytologic screening in combination with ablative therapy has helped reduce cervical cancer mortality in the developed world. Despite the success of this approach, cervical cancer remains a major cause of death, especially among women with limited access to health care. Recognition that human papillomaviruses (HPVs) are the main etiologic agent in cervical cancer suggests that a prophylactic vaccine could reduce the incidence of HPV infection and, therefore, achieve cancer control with reduced reliance on costly screening programs. In this review, the rationale for developing a prophylactic HPV vaccine and the potential impact that vaccination would have on cervical cancer screening are discussed.
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