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  • Title: [Activity of the enzymes of ethanol and acetaldehyde metabolism in rats with varying initial sensitivity to alcohol].
    Author: Bardina LR, Satanovskaia VI, Pron'ko PS, Kuz'mich AB.
    Journal: Ukr Biokhim Zh (1978); 1997; 69(1):94-9. PubMed ID: 9454388.
    Abstract:
    The experiments were carried out on male rats with different sensitivity to alcohol. To assess sensitivity to ethanol effects, we have used ethanol-induced sleep time and variations in rectal temperature of alcohol-intoxicated animals. Activity of alcohol dehydrogenase, microsomal ethanol-oxidizing system, catalase and aldehyde dehydrogenase in the liver as well as ethanol and acetaldehyde levels in the blood were determined after alcohol intoxication (3.5 g/kg, i.p., 8 days). The development of alcohol tolerance was accompanied by induction of the microsomal ethanol-oxidizing system in long-sleeping rats and in short-sleeping rats as well as by an increase in ethanol and acetaldehyde levels in the blood.
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