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  • Title: Pharmacological properties of bis-beta-hydroxypropylmalonic acid dilactone derivatives.
    Author: Sypniewska M.
    Journal: Pol J Pharmacol Pharm; 1976; 28(2):157-65. PubMed ID: 945562.
    Abstract:
    Acute toxicity and the action on CNS (employing behavioural tests) of bis-beta-hydroxypropylmalonic acid dilactone (D1) and its four derivatives (D2--D5) were investigated (Table 1) in mice and rats. The studied compounds showed low toxicity and were sometimes active just from high doses. D1 can be regarded as a sedative--hypnotic compound. In animals, the substituted dilactones induced the symptoms similar to those of tranquilizers.
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