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  • Title: Influence of food on the bioavailability of a carbamazepine slow-release formulation.
    Author: Retzow A, Schürer M, Schulz HU.
    Journal: Int J Clin Pharmacol Ther; 1997 Dec; 35(12):557-60. PubMed ID: 9455713.
    Abstract:
    The pharmacokinetics of a multiple-unit carbamazepine slow-release preparation were studied after a 12-hour fast and after a standardized breakfast in 24 healthy male volunteers. There was a small increase in mean values of AUC0-infinity and Cmax when the drug was given with food. The rate of absorption of slow-release carbamazepine, as reflected by HVD, appeared to be unchanged in the presence of food. Bioequivalence was concluded for the AUC0-infinity and HVD ratios applying the inclusion rule, thus demonstrating the lack of food interaction. The results indicate that administration of the investigated carbamazepine slow-release formulation to patients in the fasting or nonfasting state seems not to be a major consideration when deciding on the regimen.
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