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  • Title: Early detection of cardiac damage with heart fatty acid-binding protein after cardiac operations.
    Author: Suzuki K, Sawa Y, Kadoba K, Takahashi T, Ichikawa H, Kagisaki K, Ohata T, Matsuda H.
    Journal: Ann Thorac Surg; 1998 Jan; 65(1):54-8. PubMed ID: 9456095.
    Abstract:
    BACKGROUND: It is still difficult to evaluate myocardial damage in the acute phase of reperfusion in cardiac operations. We investigated the clinical significance of human heart fatty acid-binding protein (HH-FABP) for detecting myocardial damage after cardiac operations earlier than creatine kinase MB isoform or troponin-T. METHODS: Blood samples from 20 patients who underwent coronary artery bypass grafting were collected serially after reperfusion to measure serum levels of creatine kinase-MB, troponin-T, and HH-FABP. RESULTS: Serum HH-FABP levels peaked earliest after reperfusion. In addition, the maximum serum HH-FABP level was predictable immediately after reperfusion. The maximum serum HH-FABP level correlated with the maximum serum creatine kinase-MB or troponin-T level, as well as with the aortic cross-clamp time or the maximum dose of catecholamines administered after reperfusion. CONCLUSIONS: Measurements of HH-FABP allow for earlier evaluation of myocardial damage in the acute phase of reperfusion. Human heart fatty acid-binding protein may be a useful indicator of myocardial damage after cardiac operations.
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