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  • Title: Atypical adenomatous hyperplasia of the prostate: a premalignant lesion?
    Author: Cheng L, Shan A, Cheville JC, Qian J, Bostwick DG.
    Journal: Cancer Res; 1998 Feb 01; 58(3):389-91. PubMed ID: 9458077.
    Abstract:
    To better understand genetic alterations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31-35, 8p12-21, 8p22, 8q22.2, and 18q12.2 from 15 patients with AAH. DNA samples were obtained from formalin-fixed paraffin-embedded sections using tissue microdissection. We found allelic imbalance in 7 of 15 (47%) cases of AAH. Genetic changes that commonly occur in early prostatic carcinogenesis and prostate carcinoma are found in AAH. Current data provide evidence of a genetic link between some cases of AAH and carcinoma.
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