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  • Title: Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe.
    Author: Motegi F, Nakano K, Kitayama C, Yamamoto M, Mabuchi I.
    Journal: FEBS Lett; 1997 Dec 29; 420(2-3):161-6. PubMed ID: 9459302.
    Abstract:
    We cloned the myo3+ gene of Schizosaccharomyces pombe which encodes a type-II myosin heavy chain. myo3 null cells showed a defect in cytokinesis under certain conditions. Overproduction of Myo3 also showed a defect in cytokinesis. Double mutant analysis indicated that Myo3 genetically interacts with Cdc8 tropomyosin and actin. Myo3 may be implicated in cytokinesis and stabilization of F-actin cables. Moreover, the function of Myo2 can be replaced by overexpressed Myo3. We observed a modest synthetic interaction between Myo2 and Myo3. Thus, Myo2 and Myo3 seem to cooperate in the formation of the F-actin ring in S. pombe.
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