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  • Title: Changes in thyroid hormone economy following consumption of environmentally contaminated Great Lakes fish.
    Author: Leatherland JF.
    Journal: Toxicol Ind Health; 1998; 14(1-2):41-57. PubMed ID: 9460169.
    Abstract:
    Epizootics of thyroid lesions in fish and piscivorous birds that are resident in the Great Lakes region of North America suggest that there are environmental factors present in the Great Lakes ecosystem that act as potent endocrine disruptors, and that they are transferred along the food chain. This paper examines the results of wildlife studies, as well as related studies on fish-eating human populations in the region. It also re-examines the results of experimental studies of the effects of Great Lakes fish diets on the thyroid physiology of rodents and shows that the thyroid responses of fish-fed rats and mice were essentially similar to those found in rats that had been administered specific polyhalogenated aromatic hydrocarbon (PHAH) congeners or commercial polychlorinated biphenyl mixtures. However, the responses to the Great Lakes fish diets were found at PHAH exposure levels that were commonly several orders of magnitude lower than those applied in the classical toxicology studies. These findings, together with the results of the Great Lakes piscivorous bird studies and one in which captive common seals were fed "environmentally contaminated" fish, suggest that the "environmental" PHAH mixtures accumulated in fish represent a significant threat to the thyroid hormone economy, and the effects are greater than could be predicted by virtue of the known levels of active congeners in this naturally bioaccumulated PHAH mix.
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