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  • Title: [Temporal variation of genotypes and serotypes of enterohemorrhagic E Coli isolated from Chilean children with intestinal infections or hemolytic uremic syndrome].
    Author: Prado V, Martínez J, Arellano C, Levine MM.
    Journal: Rev Med Chil; 1997 Mar; 125(3):291-7. PubMed ID: 9460265.
    Abstract:
    BACKGROUND: Infections by enterohemorrhagic E. Coli may be asymptomatic, may cause diarrhea, sometimes bloody or a hemolytic uremic syndrome in 2 to 7% of children. These diseases appear sporadically or as outbreaks. Host and agent factors influence the appearance of hemolytic uremic syndrome. AIM: To study the distributions and prevalence of virulence genes and enterohemorrhagic E. Coli serogroups isolated from Chilean children. MATERIALS AND METHODS: Thirty six strains isolated from children with hemolytic uremic syndrome (8 obtained in 1988-1989, 15 obtained in 1990-1993 and 13 obtained in 1995-1996), 33 strains from asymptomatic children, obtained in similar periods and 30 strains from children with bloody diarrhea, obtained in 1995-1996 were studied. Virulence factors were investigated with a colony hybridization technique using probes that identify virulence genes. Serotypes were identified with commercial antisera. RESULTS: Both SLTI and SLTII genes predominated in strains obtained from children with hemolytic uremic syndrome in 1988-1989 and 1995-1996 and SLTI gene predominated in strains obtained in 1990-1993. Similar temporal variations in virulence genes of strains obtained from asymptomatic children were observed. SLTI/SLTII pattern predominated in strains obtained from children with bloody diarrhea and the frequency of O157 serogroup was lower, compared to strains obtained from children with hemolytic uremic syndrome. CONCLUSIONS: There was a temporal variation in toxigenic genotypes of enterohemorrhagic E. Coli strains, but no association between these genotypes and the risk for hemolytic uremic syndrome was observed.
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