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  • Title: Body-fundic gastric ulcer and Helicobacter pylori: muco-peptic cells expansion (immature cells) in Helicobacter pylori positive patients.
    Author: Testino G, Testino R.
    Journal: Acta Gastroenterol Latinoam; 1997; 27(5):309-11. PubMed ID: 9460510.
    Abstract:
    It is generally agreed that Helicobacter pylori (Hp) plays a key role in alterating regulatory factors affecting cellular proliferation during the disease process. During chronic superficial gastritis there is, in case of moderate/severe activity, a foveolar-superficial expansion of immature muco-peptic cells. In the present experience this phenomenon has been evaluated in the surrounding areas of 22 body-fundic gastric ulcer (BFGU). The 72.7% of BFGU were Hp positive. The expansion was detectable in 68.7% of Hp positive BFGU. The expansion process involves the substitution of mature cells with immature one determining a reduction of the efficacy of the mucosa barrier in association with an increment of aggressive factors (mucosal pepsins). This phenomenon in relation with host genetic susceptibility may favor peptic ulcer.
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