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  • Title: [Effect of sex hormones on lipid peroxidation in the rat aorta].
    Author: Karachentsev AN, Mel'chenko IA.
    Journal: Eksp Klin Farmakol; 1997; 60(6):13-6. PubMed ID: 9460589.
    Abstract:
    The effect of sex hormones on lipid peroxidation (LPO) in the wall of the aorta of male rats was studied in vivo and in vitro. Female sex hormones (17 beta-estradiol and progesterone) inhibited LPO in the aorta: 17 beta-estradiol caused a maximum antioxidant effect at the beginning of its action, progester one during prolonged action. Testosterone had a marked prooxidant effect, activating lipid LPO in the aorta both in vivo and in vitro whatever its concentration and duration of incubation.
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