These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The nature of the interactions of imipramine and serotonin with human lymphocytes].
    Author: Lesnichuk SA, Katukov VIu, Porodenko NV.
    Journal: Eksp Klin Farmakol; 1997; 60(6):40-3. PubMed ID: 9460597.
    Abstract:
    The work deals with the study of tritium-labeled serotonin (3H-5-hydroxytryptamine, 3H-5-HT) binding with mononuclear leukocytes (lymphocytes) isolated from human peripheral blood. It was shown that 3H-5-HT interacts specifically with the lymphocytes according to the type of reversible, saturated, and temperature-dependent receptor binding. The parameters of binding of the dissociation constant of the ligand-receptor complex and the maximum concentration of the binding centers were determined. It was shown that the tricyclic antidepressant imipramine inhibits the binding of 3H-5-HT with IC50 = 280 nm. The binding of 3H-5-HT with lymphocytes is Na-insensitive but is inhibited by Ca and Mg ions. The interrelation of 3H-5-HT with the lymphocytes differs in nature from the process of reuptake capture of 3H-5-HT by the blood platelets.
    [Abstract] [Full Text] [Related] [New Search]