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  • Title: Induction of SV40-related transplantation immunity in mice by BK virus-transformed cells.
    Author: Kato K, Iwamura Y, Kurimura T.
    Journal: Jpn J Med Sci Biol; 1979 Oct; 32(5):311-4. PubMed ID: 94612.
    Abstract:
    The reactivity of tumor-specific transplantation antigens (TSTAs) induced by SV40 and BK virus (BKV) was studied in Balb/Ccr mice with SV40-transformed tumor cells (mKSA-4AC). The mice, which had received BKV-transformed mouse or hamster cells, were highly resistant to the challenge with mKSA-4AC. The mKSA-rejected animals, however, were as susceptible as non-immunized ones to the subsequent challenge with Moloney sarcoma virus (Kirsten)-transformed cells. The result shows that BKV-transformed cells have a TSTA immunologically related closely to that induced by SV40.
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