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  • Title: Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine.
    Author: Maruyama Y, Kuribara H, Morita M, Yuzurihara M, Weintraub ST.
    Journal: J Nat Prod; 1998 Jan; 61(1):135-8. PubMed ID: 9461663.
    Abstract:
    The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.
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