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  • Title: HLA-A, B, DR, and DQ antigens in Indian patients with severe chronic rheumatic heart disease.
    Author: Maharaj B, Khedun SM, Hammond MG, van der Byl K.
    Journal: Jpn Heart J; 1997 Sep; 38(5):663-8. PubMed ID: 9462415.
    Abstract:
    To determine whether genetic factors could be involved in the pathogenesis of rheumatic heart disease, we performed HLA-A and HLA-B typing in 59 Indian patients with severe chronic rheumatic heart disease requiring cardiac surgery, and HLA-DR and HLA-DQ typing in 58 of these patients. The HLA typing was done by a standard microlymphocytotoxicity method. Patients were 12 to 59 years old (mean 32.9 years). No significant differences in HLA-A, HLA-B, HLA-DR and HLA-DQ frequencies between patients and controls were noted. The role of genetically determined immune-response factors in the pathogenesis of chronic rheumatic heart disease was not evident in this study.
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