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  • Title: Bioactive and other sesquiterpenes from Chiloscyphus rivularis.
    Author: Wu C, Gunatilaka AA, McCabe FL, Johnson RK, Spjut RW, Kingston DG.
    Journal: J Nat Prod; 1997 Dec; 60(12):1281-6. PubMed ID: 9463110.
    Abstract:
    Bioassay-directed fractionation of the methyl ethyl ketone extract of Chiloscyphus rivularis yielded five new sesquiterpenes, 12-hydroxychiloscyphone (2), chiloscypha-2,7-dione (3), 12-hydroxychiloscypha-2,7-dione (4), chiloscypha-2,7,9-trione (5), and rivulalactone (6) in addition to the known sesquiterpenes, 4-hydroxyoppositan-7-one (7), chiloscyphone (1), and isointermedeol (8). The structure and stereochemistry of rivulalactone, a novel trinorsesquiterpene, was confirmed by its synthesis starting from 1. Compound 2 showed selective bioactivity in our yeast-based DNA-damaging assay and cytotoxicity to human lung carcinoma cells.
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