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  • Title: Incorporation and release of vancomycin from poly(D,L-lactide-co-glycolide) microspheres.
    Author: Atkins TW, Peacock SJ, Yates DJ.
    Journal: J Microencapsul; 1998; 15(1):31-44. PubMed ID: 9463805.
    Abstract:
    Spherical monolithic microspheres, with a honeycomb-like internal architecture, composed of PLCG 50:50 and PLCG 75:25 and containing a range of vancomycin loadings, have been fabricated using a W/O emulsification with solvent evaporation technique. Microspheres were generated in high yield (80 wgt%) and vancomycin incorporation, confirmed using the displacement of DSC thermograms, had no significant effect on microsphere size distribution (5-50 microns). The vancomycin encapsulation efficiency was high (> 64%) and release profiles were characterized by a substantial initial burst release and a subsequent low-level sustained release extending up to 30 days depending upon the fabrication polymer, % vancomycin loading and incubation medium used. In both Hank's buffer and newborn calf serum the mean total cumulative release of vancomycin from microspheres increased significantly with theoretical percentage loading.
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