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  • Title: Double high-dose chemotherapy with autologous peripheral stem cell rescue in relapsed Wilms' tumor.
    Author: Maurer K, Heitger A, Schwaighofer H, Fink FM, Niederweiser D.
    Journal: Bone Marrow Transplant; 1997 Dec; 20(12):1111-3. PubMed ID: 9466289.
    Abstract:
    We performed double high-dose chemotherapy (HDCT) and autologous stem cell rescue (ASCR) on an 8-year-old girl after relapse of Wilms' tumor with unfavorable histology. Relapse occurred while the patient was still on first-line therapy and showed multiple adverse prognostic features. Since depleted hematopoietic reserves restricted further conventional therapy, a double HDCT approach was chosen to achieve maximal dose intensity. Four years after relapse the girl is in second remission and well. Double HDCT with ASCR may represent a feasible approach to rescue extensively pretreated patients with recurrent Wilms' tumor of unfavorable histology.
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