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  • Title: Hepatitis C virus infection and lichen planus: a short review.
    Author: Lodi G, Porter SR.
    Journal: Oral Dis; 1997 Jun; 3(2):77-81. PubMed ID: 9467346.
    Abstract:
    OBJECTIVE: To review the current literature regarding the association of lichen planus (LP) and liver disease, with particular attention to the association of the oral variant of the disease with hepatitis C virus (HCV) infection. MATERIALS AND METHODS: Available literature of the possible association of LP with systemic disorders, in particular chronic hepatic disease, has been reviewed. RESULTS: LP is sometimes associated with infectious or autoimmune disease and/or neoplasia, however an aetiological association between LP and these disorders seems unlikely. A more consistent association exists between LP and chronic hepatic disease. The precise cause of this association is not known. However, in the last 6 years a notable association between HCV infection and LP has been observed, particularly in patients in Spain, Italy and Japan. The pathogenesis of this possible HCV-associated LP is not known, but it may involve a cell mediated response to an altered epithelial antigen. CONCLUSION: There is now evidence to suggest a significant association between HCV infection and LP in some groups of patients.
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