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  • Title: Severe combined immunodeficiency with thymic mast cell hyperplasia.
    Author: Wise WS, Still WJ, Joshi VV.
    Journal: Arch Pathol Lab Med; 1976 May; 100(5):283-6. PubMed ID: 946756.
    Abstract:
    The autopsy finding on an infant with severe combined immunodeficiency was marked thymic mast cell hyperplasia. The clinical immune status showed a deficit in T (thymus derived) lymphocytes and low immunoglobulin levels. The autopsy showed the histologic pattern designated thymic alymphoplasia and a marked lack of development of the reticuloendothelial organs. The mast cell hyperplasia may be the result of an antigenic stimulus early in embryonic life and/or the result of mast cell differentiation at the expense of normal thymic lymphoid development caused by a genetic defect.
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