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  • Title: Telomerase is an unusual RNA-containing enzyme. A review.
    Author: Dokudovskaya SS, Petrov AV, Dontsova OA, Bogdanov AA.
    Journal: Biochemistry (Mosc); 1997 Nov; 62(11):1206-15. PubMed ID: 9467844.
    Abstract:
    Telomeres, the natural ends of linear eukaryotic chromosomes, are essential for protecting chromosomes from degradation and fusion. The synthesis of telomere DNA repeats in most eukaryotes is performed by a special enzyme, telomerase. Telomerase, a ribonucleoprotein enzyme, is a specialized reverse transcriptase utilizing its RNA moiety as a template for synthesis of telomeric DNA. Enzymatic properties and results of comparative analysis of telomerase RNA and protein structures from different eukaryotic systems are discussed in this review.
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