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  • Title: Preparation, characterization, and in vitro release of ibuprofen from AI2O3/PLA/PMMA composites.
    Author: Vallet-Regí M, Granado S, Arcos D, Gordo M, Cabañas MV, Ragel CV, Salinas AJ, Doadrio AL, San Román J.
    Journal: J Biomed Mater Res; 1998 Mar 05; 39(3):423-8. PubMed ID: 9468051.
    Abstract:
    The preparation, characterization, and in vitro release of Ibuprofen from Al2O3, poly(L-lactic acid) (PLLA), and polymethylmethacrylate (PMMA) composites are described. The release process of the anti-inflammatory drug after the immersion of composites in a buffered solution is analyzed. The rate of Ibuprofen release is related to the crystalline or amorphous form of the drug. The presence of a ceramic component, alpha-Al2O3, and a biodegradable polymer, PLLA, facilitates both Ibuprofen crystallization and drug release. In addition, these composite systems modulate the release of the stereoisomers R(-) and S(+) of the drug.
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