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  • Title: ABI2, a second protein phosphatase 2C involved in abscisic acid signal transduction in Arabidopsis.
    Author: Rodriguez PL, Benning G, Grill E.
    Journal: FEBS Lett; 1998 Jan 16; 421(3):185-90. PubMed ID: 9468303.
    Abstract:
    The abi2-1 (abscisic acid insensitive) mutant of Arabidopsis thaliana shows abscisic acid (ABA) insensitivity with respect to seed germination and vegetative ABA responses. We identified the ABI2 gene by a combination of positional mapping and homology to ABI1. The ABI2 protein shows 80% amino acid sequence identity to ABI1, a protein phosphatase 2C (PP2C) involved in ABA signaling. The mutation that confers the abi2-1 phenotype is equivalent to the mutation previously identified in abi1-1 and the resulting Gly168Asp abi2 protein shows a reduced PP2C activity. Thus, a pair of highly homologous PP2Cs regulate ABA signaling.
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