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  • Title: Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
    Author: Fontecave M, Lepoivre M, Elleingand E, Gerez C, Guittet O.
    Journal: FEBS Lett; 1998 Jan 16; 421(3):277-9. PubMed ID: 9468322.
    Abstract:
    Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.
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