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  • Title: [Biparametric analysis of the apoptotic index and the proliferation index (KI-67) in solid tumors].
    Author: Mangili F, Cigala C, Gattuso C.
    Journal: Pathologica; 1997 Aug; 89(4):384-9. PubMed ID: 9471606.
    Abstract:
    INTRODUCTION: Cell kinetic data are important indicators of the aggressiveness of tumor and treatment response. In this study biparametric analysis of proliferation and apoptotic index was performed on paraffin-embedded tissue from certain neoplasia. MATERIAL AND METHODS: We studied 107 cases of neoplastic and non neoplastic lesions. For each case, on the same section, TUNEL reaction and immunohistochemical protein Ki67 expression analysis were performed. RESULTS: On 102 out of 107 cases (95.3%) we obtained valid results both about apoptotic and proliferative indices. CONCLUSIONS: This method could supply, at the same time, interesting information about the two possible different patterns of neoplastic growth: one related to an increase fraction of proliferating cells, the other to decrease in apoptotic cell death. Cell kinetic data may have interesting implications on therapeutic choice.
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