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  • Title: Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.
    Author: Visvader JE, Fujiwara Y, Orkin SH.
    Journal: Genes Dev; 1998 Feb 15; 12(4):473-9. PubMed ID: 9472016.
    Abstract:
    The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.
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