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  • Title: Characterization of Mycobacterium avium complex related mycobacteria isolated from an African environment and patients with AIDS.
    Author: Fonteyne PA, Kunze ZM, De Beenhouwer H, Dumonceau JM, Dawson DJ, McFadden JJ, Portaels F.
    Journal: Trop Med Int Health; 1997 Feb; 2(2):200-7. PubMed ID: 9472306.
    Abstract:
    Thirteen isolates from African AIDS patients and from the environment in Zaire were identified as members of the Mycobacterium avium complex by phenotypic tests. RFLP analysis showed that the isolates belong to a genetically homogeneous cluster. The 16S rRNA sequence analysis suggests a close relationship with the P-49 strain (ATCC 35847), a reference strain for the serotype 7 of M. avium complex. This work shows the close relationship between certain M. avium complex strains responsible for disseminated infection in AIDS patients and M. avium complex strains isolated from the environment in Zaire. Further, our findings confirm that atypical mycobacteria may disseminate in AIDS patients in Africa and suggest that infection in these patients probably originates in their environment.
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