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  • Title: Alterations in renal and hepatic nitrogen metabolism in rats during HCl ingestion.
    Author: Lardner AL, O'Donovan DJ.
    Journal: Metabolism; 1998 Feb; 47(2):163-7. PubMed ID: 9472964.
    Abstract:
    The effect of prolonged metabolic acidosis on hepatic and renal enzymes associated with nitrogen metabolism was investigated. The rates of urinary ammonia and urea excretion were also determined. Administration of 9 mmol HCl daily for 8 days resulted in severe metabolic acidosis. The activity of the first two enzymes of the urea cycle, carbamoyl phosphate synthetase (CPS) and ornithine transcarbamoylase (OTC), was 30% greater in chronically acidotic rats than in pair-fed controls. There was also a fivefold increase in renal phosphate-dependent glutaminase (PDG) activity and an 18 to 24-fold increase in renal ammonia excretion. Urea excretion was not constant in the acidotic group, decreasing during the first 4 days and gradually returning to pair-fed control levels between the fourth and eighth day. The return to control levels of urinary urea excretion coincided with the plateau of urinary ammonia excretion that occurred by day 4 in the acidotic group. A similar pattern of urea nitrogen excretion has been observed in both NH4Cl and HCl acidosis, ie, an initial decrease in urea excretion followed by a gradual increase with time. These results suggest that hepatic urea synthesis does not play a significant role in long-term regulation of the acid-base balance in rats during chronic metabolic acidosis.
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