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  • Title: Hypertrophic response of the kidney in indomethacin treated rats.
    Author: Vasadi P, Selmeci L, Pósch E, Hársing L.
    Journal: Acta Physiol Acad Sci Hung; 1979; 53(4):427-32. PubMed ID: 94742.
    Abstract:
    Indomethacin, a potent inhibitor of prostaglandin (PG) synthesis administered to rats in a total dose of 2 x 4.5 mg/kg i.v. for 2 days enhanced compensatory renal hypertrophy following unilateral nephrectomy (UN). The same drug given to rats with intact kidneys in a total dose of 4 x 4.5 mg/kg i.p. in 2 days increased kidney weight renal RNA content and decreased renal acidic ribonuclease activity. It remains to be elucidated whether the suppression of PG synthesis and/or other pharmacological effects of indomethacin account for these findings.
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