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  • Title: [The activity of renal glomeruli and tubules during uncomplicated pregnancy: influence of delivery on urinary excretion of albumin, beta 2-microglobulin and Tamm-Horsfall protein].
    Author: Bockenek S, Duława J, Kokot F, Kokot M, Bar A.
    Journal: Ginekol Pol; 1997 May; 68(5A):226-31. PubMed ID: 9480237.
    Abstract:
    There were examined the influence the various types of delivery (spontaneous, oxytocin induced, cesarean section) on the value of albumin's (marker of glomerular activity), beta 2-microglobulin's (beta 2-M) (marker of activity proximal renal tubule) and Tamm-Horsfall's protein (pTH) (as a marker of activity distal's renal tubule) excretion in 50 healthy pregnant women without clinical symptoms of nephropathy. There were also estimated creating concentration in plasma and value of creating excretion in urine before and after delivery in every women. There were stated a little increase of albumin and beta 2-microglobulin but proper excretion (pTH) in urine in every group of pregnant women. There were estimated increase of albumin and pTH excretion in urine after spontaneous delivery, oxytocin inducted or cesarean section, particularly in women after cesarean section. The type of delivery had not an effect on the beta 2-microglobulin's urine excretion. The results of conducted researches suggest occurrence of functional changes in both renal glomeruli and tubules in physiologic pregnancy. The type of delivery reveals differentiated in quantity's respect the influence on albumin's and pTH excretion, but it has not an effect on beta 2-microglobulin's urine excretion.
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