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Title: Control of heat produced during ATP hydrolysis by the sarcoplasmic reticulum Ca(2+)-ATPase in the absence of a Ca2+ gradient. Author: de Meis L. Journal: Biochem Biophys Res Commun; 1998 Feb 13; 243(2):598-600. PubMed ID: 9480854. Abstract: The amount of heat produced during the hydrolysis of ATP by the sarcoplasmic reticulum Ca(2+)-ATPase was found to vary depending on the Ca2+ concentration in the medium. When the CaCl2 concentration is raised from 0.1 to 2.0 mM a part of the energy derived from ATP hydrolysis is not dissipated as heat but it is used by the enzyme to resenthesize a small fraction of the ATP previously cleaved. Thus, Ca2+ seems to regulate the ATPase in such a way as to vary the fraction of energy derived from ATP hydrolysis which is converted into heat and that which is conserved as chemical energy.[Abstract] [Full Text] [Related] [New Search]