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  • Title: Cyclic changes of cervical mucus enzymes related to the time of ovulation II. Amino peptidase and esterase.
    Author: Moghissi KS, Syner FN, Borin B.
    Journal: Obstet Gynecol; 1976 Sep; 48(3):347-50. PubMed ID: 948379.
    Abstract:
    The enzymes amino peptidase and esterase were identified in human cervical mucus. Their concentration was serially determined during a menstrual cycle in 5 normal ovulatory women and correlated with the time of ovulation as monitored by the basal body temperature and radioimmunoassay of serum luteinizing hormone (LH), progesterone, and estradiol (E2). The activity of both enzymes decreased at midcycle just before the LH surge and began to rise after ovulation. The preovulatory decline in enzyme activity was significant for esterase but not for amino peptidase. The site of production and functional significance of these enzymes are not at present identified. Changes in the cervical mucus content of the enzymes amino peptidase and esterase were determined over the menstrual cycle in 5 normal ovulatory women. The time of ovulation was estimated by recording basal body temperature and radioimmunoassay of serum luteinizing hormone (LH), progesterone and estradiol. Immediately prior to the midcycle surge of LH, both enzymes showed decreased activity, with the decrease in esterase activity being statistically significant (p less than .008). After ovulation, both enzymes showed increased activity. It remains to determine whether these enzymes play a role in the interaction between sperm and cervical mucus.
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