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Title: [Properties of extracellular products produced by group A streptococci isolated from patients with streptococcal toxic shock syndrome]. Author: Suzuki J, Matsubuchi S, Yoshihara E, Kobayashi S, Okamura K, Okuda T, Okazaki M, Furuya N, Uchimura H, Tokunaga T, Shimazaki S. Journal: Kansenshogaku Zasshi; 1997 Dec; 71(12):1187-92. PubMed ID: 9483877. Abstract: Extracellular products of group A streptococci isolated from patients with streptococcal toxic shock syndrome (STSS) were examined. The outline of the discussion of the 3 products are as follows; streptolysin O (SLO), proteinase and erythrogenic toxin. SLO and proteinase showed a relatively large amount of products more than erythrogenic toxin. SLO produced by group A streptococci isolated from the patient with STSS had an isoelectric point (pI) of 6.0 and a molecular weight of 64,000 and showed hemolytic activity in the presence of 2-mercaptoethanol (2-ME). Furthermore, the hemolytic activities of all components were inhibited by gamma-globulin and cholesterol. Proteinase had pIs of 8.7 and 8.9, and a molecular weight of 21,000. These data suggest that STSS clinical criteria probably reflects a characteristic of a large amount of products of individual S. pyogenes isolates.[Abstract] [Full Text] [Related] [New Search]