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  • Title: Unmyelinated nerve fibers in sural nerve in pure autonomic failure.
    Author: Kanda T, Tomimitsu H, Yokota T, Ohkoshi N, Hayashi M, Mizusawa H.
    Journal: Ann Neurol; 1998 Feb; 43(2):267-71. PubMed ID: 9485071.
    Abstract:
    We examined sural nerve biopsy specimens from 7 patients with pure autonomic failure (PAF). The mean unmyelinated nerve fiber density in these patients was 40% less than in age-matched controls. Increased numbers of clusters of collagen pockets not containing unmyelinated axons were the most prominent finding in PAF. This appears to reflect recent dropout of a group of sympathetic efferents and suggests grouping of unmyelinated fibers by modality at the level of the sural nerve trunk.
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