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  • Title: Synergy between TGF-beta 3 and NT-3 to promote the survival of spiral ganglia neurones in vitro.
    Author: Marzella PL, Clark GM, Shepherd RK, Bartlett PF, Kilpatrick TJ.
    Journal: Neurosci Lett; 1998 Jan 09; 240(2):77-80. PubMed ID: 9486476.
    Abstract:
    Transforming growth factor-betas (TGF-betas) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF-beta3 and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF-beta3 supports neuronal survival in a concentration-dependent manner. Moreover TGF-beta3 and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion.
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