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  • Title: Synergistic activity of trovafloxacin with other agents against gram-positive and -negative organisms.
    Author: Visalli MA, Bajaksouzian S, Jacobs MR, Appelbaum PC.
    Journal: Diagn Microbiol Infect Dis; 1998 Jan; 30(1):61-4. PubMed ID: 9488833.
    Abstract:
    The synergistic activity of trovafloxacin with other agents against 55 Gram-positive and -negative bacteria was determined by checkerboard titration. Synergistic fractional inhibitory concentration (FIC) indices (< or = 0.5) were seen in two methicillin-susceptible and one methicillin-resistant Staphyloccocus aureus with teicoplanin, one of each of the latter two with vancomycin; one methicillin-resistant coagulase-negative Staphylococcus with rifampin and one with fusidic acid; five Stenotrophomonas maltophilia with cefoperazone; three Pseudomonas aeruginosa with ticarcillin/clavulanate, four with aztreonam, two with ceftazidime, one with tobramycin, one with cefoperazone, and one with ceftriaxone; one pneumococcus with ceftriaxone; one Enterococcus faecalis with ceftriaxone, and one with vancomycin; two Bacteroides fragilis with metronidazole, two with clindamycin, and one with cefoxitin; and one Clostridium perfringens with metronidazole and one with clindamycin. All other FIC indices were additive/indifferent (0.51-2.0), and no antagonistic FIC indices (> 4.0) were observed.
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