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  • Title: [Soluble TNF-alpha receptors].
    Author: Jabłońska E.
    Journal: Postepy Hig Med Dosw; 1997; 51(5):567-75. PubMed ID: 9489455.
    Abstract:
    Soluble cytokine receptors are more general phenomena and play a wider physiological role in the regulation of the immune system than previously recognized. Soluble TNF receptors--sTNF-Rp55 and sTNF-Rp75 by ability to bind to free TNF-alpha might play a regulatory role in a variety of normal and abnormal reactions mediated by TNF-alpha. Increase of sTNF-Rs levels have been observed in the serum of patients with a different diseases. Measurement of soluble TNF receptors concentrations seems to be a significant indicator in prognostic estimation of some diseases. Additionally, bioengineered soluble receptors may prove useful as specific cytokine-inhibiting therapeutic agents.
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