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  • Title: [The action of insulin on cardiac contractility in active, hibernating and arousing susliks Citellus undulatus].
    Author: Nakipova OV, Gaĭnullin RZ, Safronova VG, Kosarskiĭ LS, Bakaneva BF, Ignat'ev DA, Amerkhanov ZG, Kolaeva SG, Kukushkin NI, Solomonov NG.
    Journal: Biofizika; 1997; 42(6):1297-300. PubMed ID: 9490118.
    Abstract:
    During the deep hibernation (at 5-6 degrees C of the heart temperature) and during arousal from hibernation (at 15-16 degrees C) insulin have no effect on contractility. Two opposite inotropic effects of insulin at concentrations 0.1-50 nM were found at higher temperature of arousing: a transient positive inotropic effect between 21-28 degrees C, and a negative one (about 20-30% from the control value) above 28 degrees C. In active summer and winter animals insulin produced mainly the negative inotropic effect.
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