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  • Title: Lithium-induced nephrogenic diabetes insipidus.
    Author: Juhl RP, Kronfol Z, Tsuang MT.
    Journal: Am J Hosp Pharm; 1976 Aug; 33(8):843-5. PubMed ID: 949067.
    Abstract:
    The etiology, diagnosis and management of lithium-induced diabetes insipidus (LIDI) is discussed, including the presentation of a case report. It is suggested that lithium provokes LIDI by decreasing the responsive ness of the kidney to the antidiuretic hormone. Lithium-induced polyuria may be managed by concomitant treatment with a thiazide diuretic or discontinuation of the lithium. Caution must be employed, however, when using thiazides with lithium as these diuretics decrease renal clearance of lithium.
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